It is well documented in the literature that low levels of testosterone are a risk factor for the development of type 2 diabetes, obesity with a predominance of visceral fat (abdominal fat), insulin resistance, and elevated blood glucose levels.


In fact, the presence of low testosterone is predictive for the development of type 2 diabetes in males. Cardiovascular conditions such as coronary artery disease and hypertension are also increased when testosterone levels are found the be low.


In men, testosterone levels gradually decline with age whereby serum total testosterone levels decrease by approximately 1% per year after the age of 30. This rate of decline in testosterone levels is accelerated when the presence of co-morbid conditions exists such as chronic kidney disease, liver disease, pulmonary disease, or the presence of cancer.


The age-related decline in production of testosterone is due to two different processes. One, the production of testosterone in the testis decreases. Two, the signal from the brain via luteinizing hormone secreted by the pituitary gland decreases. Of note the rate of metabolic clearance of testosterone also decreases with age; this fortunately lessens the rate of testosterone decline.


This association is featured in this article to illustrate the complex metabolic changes that occur within the body both as a normal response to aging but also to an abnormal response associated with disease occurrence and progression. In males, testosterone levels significantly predispose males to weight gain, insulin resistance, abdominal fat formation, and the development of type 2 diabetes.


The Metabolism Correction Program for weight loss evaluates each metabolic pathway responsible for weight gain as well as insulin resistance. Weight loss strategies that focus on calories or weight loss medications do not address the underlying causes of an abnormal metabolism and thus their rates of long-term success are underwhelming.

The Metabolism Clinic is established as the destination for weight loss and reversal of diabetes. Based in Charlotte, North Carolina.