Obesity continues to be a serious medical condition that is affecting more than a third of the U.S population. Unfortunately, most of the weight loss clinics continue to use the wrong methods for treating obesity. In this article, we will discuss one of the weight loss medications that is often used in weight loss clinics.


Phendimetrazine is an appetite suppressant that is used to induce weight loss. It has a very similar structure and action to amphetamines and it is closely related to another weight loss medication Phentermine.


It suppresses appetite and places the patient in a semi-starvation mode. Usually, the patient is put on a very low calorie restrictive diet and they do not feel the hunger because of this medication.


Weight loss usually stops in few months as the body start to decrease its basal metabolic rate and decreases its core temperature to save energy. The drug should only be taken for a short period of time as it has many side effects. Most patients regain all the weight that was lost after stopping the drug.


This drug has many side effects such as:

  • Cardiovascular: Flushing, hypertension, ischemic events, palpitations, tachycardia, valvular disease (regurgitant)
  • Central nervous system: Agitation, dizziness, headache, insomnia, overstimulation, psychosis, restlessness
  • Endocrine & metabolic: Changes in libido
  • Gastrointestinal: Constipation, diarrhea, nausea, stomach pain, xerostomia
  • Genitourinary: Dysuria, urinary frequency
  • Neuromuscular & skeletal: Tremor
  • Ocular: Blurred vision, mydriasis
  • Respiratory: Primary pulmonary hypertension
  • Miscellaneous: Diaphoresis, tachyphylaxis


Phendimetrazine is pharmacologicaly related to amphetamines making it have a very high potential for drug abuse. Prolonged use can lead to dependency and it should only be used smallest quantity to minimize the possibility of overdose. When the drug is stopped, the patient may experience severe depression and fatigue.


Another major problem with this medication is that your body gets used to it in few weeks the drug loses it appetite suppressant effects while it continues to have its adverse effects.


The Metabolism Clinic warns against the use of Phendimetrazine for weight loss. It does not address the actual causes of obesity which is problems in the metabolism. The drug has many serious side effects and the weight loss achieved using this drug is very temporary. When stopping it, patients experience withdrawal symptoms and most of the patients regain all the weight back and in some cases even they end up with more weight than what they started with.

The Metabolism Clinic is established as the destination for weight loss and reversal of diabetes. Based in Charlotte, North Carolina. www.themetabolismclinic.com